Issue 41, 2013

Tuning molecular interactions in lipid-oligonucleotides assemblies via locked nucleic acid (LNA)-based lipids

Abstract

Hybrid nucleotide-lipids containing locked nucleic acid (LNA) show enhanced hybridization properties with complementary single strand RNAs compared to DNA lipid analogues. The LNA adenosine lipid features unique binding properties with a high binding affinity for poly-uridine and the entropically driven formation of a stable complex (Kd ≈ 43 nM). Enhanced hybridization properties of LNA-based lipids should be applicable for the development of oligonucleotide (ON) delivery systems or as small molecule binders to RNA for novel therapeutic strategies.

Graphical abstract: Tuning molecular interactions in lipid-oligonucleotides assemblies via locked nucleic acid (LNA)-based lipids

Supplementary files

Article information

Article type
Paper
Submitted
25 Jun 2013
Accepted
27 Aug 2013
First published
29 Aug 2013

Org. Biomol. Chem., 2013,11, 7108-7112

Tuning molecular interactions in lipid-oligonucleotides assemblies via locked nucleic acid (LNA)-based lipids

A. Patwa, G. Salgado, F. Dole, L. Navailles and P. Barthélémy, Org. Biomol. Chem., 2013, 11, 7108 DOI: 10.1039/C3OB41707G

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