Cu(ii)-catalyzed highly regio- and stereoselective construction of C–C double bonds: an efficient method for the ketonization–olefination of indoles†
Abstract
A general and efficient method for the cross-coupling of indoles with β-keto esters by using TEMPO/CuSO4·5H2O in air as oxidant has been developed. This reaction features high functional-group compatibility and an excellent selectivity. This methodology provides an alternative approach for the ketonization–olefination of indoles in moderate to good yields.