Issue 41, 2013

Practical oxazole synthesis mediated by iodine from α-bromoketones and benzylamine derivatives

Abstract

The reagent system of I2/K2CO3 could efficiently promote the oxazole synthesis from α-bromoketones and benzylamine derivatives in DMF. This method was not only suitable for 2,5-diaryl oxazole synthesis but also for 2,4,5-trisubstituted oxazole and 5-alkyl/alkenyl oxazole synthesis. Furthermore, this method was successfully applied to a one-step synthesis of a natural product halfordinol in 62% yield.

Graphical abstract: Practical oxazole synthesis mediated by iodine from α-bromoketones and benzylamine derivatives

Supplementary files

Article information

Article type
Paper
Submitted
31 Jul 2013
Accepted
30 Aug 2013
First published
30 Aug 2013

Org. Biomol. Chem., 2013,11, 7123-7128

Practical oxazole synthesis mediated by iodine from α-bromoketones and benzylamine derivatives

W. Gao, R. Wang and C. Zhang, Org. Biomol. Chem., 2013, 11, 7123 DOI: 10.1039/C3OB41566J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements