Issue 34, 2013
From the journal:

Organic & Biomolecular Chemistry

Synthesis of alkylcarbonate analogs of O-acetyl-ADP-ribose†

Marcela Dvorakova,ab   Radim Nencka,c   Milan Dejmek,c   Eva Zbornikova,c   Anna Brezinova,c   Marie Pribylova,a   Radek Pohl,c   Marie E. Migaudd  and  Tomas Vanek*a  

* Corresponding authors

a Institute of Experimental Botany, Academy of Sciences of Czech Republic, v.v.i., Rozvojova 263, Prague 6, Czech Republic
E-mail: vanek@ueb.cas.cz, dvorakova@ueb.cas.cz, pribylova@ueb.cas.cz
Fax: +420 225106832
Tel: +420 225106804

b Faculty of Natural Sciences, Charles University in Prague, Albertov 6, Prague 2, Czech Republic

c Institute of Organic Chemistry and Biochemistry, Academy of Sciences of Czech Republic, v.v.i., Flemingovo nam. 2, Prague 6, Czech Republic
E-mail: radim.nencka@uochb.cas.cz, dejmek@uochb.cas.cz, zbornikova@uochb.cas.cz, anna.brezinova@uochb.cas.cz, pohl@uochb.cas.cz

d School of Pharmacy, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast, Northern Ireland, UK BT9 7BL
E-mail: m.migaud@qub.ac.uk
Tel: +44 (0)2890 9726 89

Abstract

The non-hydrolyzable alkylcarbonate analogs of O-acetyl-ADP-ribose have been synthesized from the phosphorylated ribose derivatives after coupling with AMP morpholidate promoted by mechanical grinding. The analogs were assessed for their ability to inhibit the human sirtuin homolog SIRT1.

Graphical abstract: Synthesis of alkylcarbonate analogs of O-acetyl-ADP-ribose

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Article information

DOI
https://doi.org/10.1039/C3OB41016A
Article type
Paper
Submitted
15 May 2013
Accepted
28 Jun 2013
First published
03 Jul 2013

Org. Biomol. Chem., 2013,11, 5702-5713

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Synthesis of alkylcarbonate analogs of O-acetyl-ADP-ribose

M. Dvorakova, R. Nencka, M. Dejmek, E. Zbornikova, A. Brezinova, M. Pribylova, R. Pohl, M. E. Migaud and T. Vanek, Org. Biomol. Chem., 2013, 11, 5702 DOI: 10.1039/C3OB41016A

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