Issue 29, 2013
From the journal:

Organic & Biomolecular Chemistry

Various cyclization scaffolds by a truly Ugi 4-CR†

Mantosh K. Sinha,a   Kareem Khoury,a   Eberhardt Herdtweckb  and  Alexander Dömling*ac  

* Corresponding authors

a University of Pittsburgh, Biomedical Science Tower 3, 3501 Fifth Avenue, Pittsburgh, USA

b Technische Universität München, Department Chemie, Lehrstuhl für Anorganische Chemie, Lichtenbergstrasse 4, D-85747 Garching bei Munchen, Germany

c University of Groningen, Department of Drug Design, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands
E-mail: a.s.s.domling@rug.nl

Abstract

Efficient access to a large chemical space based on new scaffolds with defined 3D conformations and highly variable in the side chains is needed to find novel functional materials. Four heterocyclic scaffolds based on a four component Ugi reaction of α-amino acids, oxo components, isocyanides and primary or secondary amines suitably functionalized are described. A handful of examples are described for each scaffold.

Graphical abstract: Various cyclization scaffolds by a truly Ugi 4-CR

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Article information

DOI
https://doi.org/10.1039/C3OB40523K
Article type
Paper
Submitted
14 Mar 2013
Accepted
17 May 2013
First published
20 May 2013

Org. Biomol. Chem., 2013,11, 4792-4796

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Various cyclization scaffolds by a truly Ugi 4-CR

M. K. Sinha, K. Khoury, E. Herdtweck and A. Dömling, Org. Biomol. Chem., 2013, 11, 4792 DOI: 10.1039/C3OB40523K

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