Issue 15, 2013
From the journal:

Organic & Biomolecular Chemistry

Phthalide: a direct building-block towards P,O and P,N hemilabile ligands. Application in the palladium-catalysed Suzuki–Miyaura cross-coupling of aryl chlorides†

James McNulty*a  and  Kunal Keskara  

* Corresponding authors

a Department of Chemistry and Chemical Biology, McMaster University, Hamilton, Ontario, Canada
E-mail: jmcnult@mcmaster.ca
Fax: (+1)-905-522-2509
Tel: (+1)-905-525-9140 Ext. 27393

Abstract

The direct synthesis of new hemilabile ligands from the economical, readily available lactone phthalide is described. Pd-complexes of one such ligand were found highly effective in general Suzuki–Miyaura cross-coupling reactions, including deactivated and hindered aryl chlorides.

Graphical abstract: Phthalide: a direct building-block towards P,O and P,N hemilabile ligands. Application in the palladium-catalysed Suzuki–Miyaura cross-coupling of aryl chlorides

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Article information

DOI
https://doi.org/10.1039/C3OB40198G
Article type
Communication
Submitted
29 Jan 2013
Accepted
27 Feb 2013
First published
27 Feb 2013

Org. Biomol. Chem., 2013,11, 2404-2407

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Phthalide: a direct building-block towards P,O and P,N hemilabile ligands. Application in the palladium-catalysed Suzuki–Miyaura cross-coupling of aryl chlorides

J. McNulty and K. Keskar, Org. Biomol. Chem., 2013, 11, 2404 DOI: 10.1039/C3OB40198G

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