Direct acylation of N-benzyltriflamides from the alcohol oxidation level via palladium-catalyzed C–H bond activation

Jihye Park; Aejin Kim; Satyasheel Sharma; Minyoung Kim; Eonjeong Park; Yukyoung Jeon; Youngil Lee; Jong Hwan Kwak; Young Hoon Jung; In Su Kim

doi:10.1039/C3OB40140E

Direct acylation of N-benzyltriflamides from the alcohol oxidation level viapalladium-catalyzed C–H bond activation†

Jihye Park,^a Aejin Kim,^a Satyasheel Sharma,^ab Minyoung Kim,^a Eonjeong Park,^a Yukyoung Jeon,^a Youngil Lee,^b Jong Hwan Kwak,^a Young Hoon Jung^a and In Su Kim*^a

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^a School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea
E-mail: insukim@skku.edu
Fax: +82 31 292 8800
Tel: +82 31 290 7788

^b Department of Chemistry, University of Ulsan, Ulsan 680-749, Republic of Korea

Abstract

A palladium-catalyzed ortho-acylation of N-benzyltriflamides from the alcohol oxidation level via C–H bond activation is described. These transformations have been applied to a wide range of substrates, and typically proceed with excellent levels of chemoselectivity and with high functional group tolerance.

Organic & Biomolecular Chemistry

Direct acylation of N-benzyltriflamides from the alcohol oxidation level viapalladium-catalyzed C–H bond activation†

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Direct acylation of N-benzyltriflamides from the alcohol oxidation level via palladium-catalyzed C–H bond activation

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