Issue 11, 2013

Direct use of formamides as amino group sources via C–N bond cleavage: a catalytic oxidative synthesis of α-ketoamides from acetophenones and formamides under metal-free conditions

Abstract

An efficient and direct use of formamides as amino group sources for the synthesis of α-ketoamides was developed under metal-free conditions. The reaction was based on the oxidative coupling of acetophenones with formamides and generated the desired products in good yields in the presence of t-BuOOH/I2/PhCO2H.

Graphical abstract: Direct use of formamides as amino group sources via C–N bond cleavage: a catalytic oxidative synthesis of α-ketoamides from acetophenones and formamides under metal-free conditions

Supplementary files

Article information

Article type
Paper
Submitted
16 Dec 2012
Accepted
14 Jan 2013
First published
16 Jan 2013

Org. Biomol. Chem., 2013,11, 1867-1873

Direct use of formamides as amino group sources via C–N bond cleavage: a catalytic oxidative synthesis of α-ketoamides from acetophenones and formamides under metal-free conditions

Q. Zhao, T. Miao, X. Zhang, W. Zhou and L. Wang, Org. Biomol. Chem., 2013, 11, 1867 DOI: 10.1039/C3OB27433K

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