Issue 15, 2013
From the journal:

Organic & Biomolecular Chemistry

Conversion of aldoximes into nitriles and amides under mild conditions†

Koujiro Tambaraa  and  G. Dan Pantoş*b  

* Corresponding authors

a The University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge, United Kingdom
E-mail: kt287@cam.ac.uk
Fax: +44 (0)1223 336362
Tel: +44 (0)2113 336300

b Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom
E-mail: g.d.pantos@bath.ac.uk
Fax: +44 (0)1225 386231
Tel: +44 (0)1225 386444

Abstract

A series of Pd(en)X2 salts were used as catalysts for the conversion of aldoximes into nitriles and amides. Highlights of this protocol include the use of inexpensive polar solvents, including water, and moderate reaction temperatures. A high degree of selectivity in the reaction outcome was observed when using aliphatic vs. aromatic/conjugated aldoximes.

Graphical abstract: Conversion of aldoximes into nitriles and amides under mild conditions

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Article information

DOI
https://doi.org/10.1039/C3OB27362H
Article type
Paper
Submitted
06 Dec 2012
Accepted
11 Feb 2013
First published
12 Feb 2013

Org. Biomol. Chem., 2013,11, 2466-2472

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Conversion of aldoximes into nitriles and amides under mild conditions

K. Tambara and G. D. Pantoş, Org. Biomol. Chem., 2013, 11, 2466 DOI: 10.1039/C3OB27362H

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