Issue 10, 2013
From the journal:

Organic & Biomolecular Chemistry

An efficient Au-catalyzed synthesis of isomukonidine, clausine L, mukonidine, glycosinine, mukonal, and clausine V from propadienyl methyl ether†

Youai Qiu,a   Dengke Ma,a   Chunling Fu*a  and  Shengming Ma*a  

* Corresponding authors

a Laboratory of Molecular Recognition and Synthesis, Department of Chemistry, Zhejiang University, Hangzhou 310027, People's Republic of China
E-mail: masm@sioc.ac.cn
Fax: +86-21-64167510

Abstract

Naturally occurring carbazole alkaloids such as isomukonidine, clausine L, mukonidine, glycosinine, mukonal, and clausine V have been synthesized through a gold-catalyzed cyclization reaction of 1-(indol-2-yl)-2-methoxy-2,3-allenols, which are readily available from indolecarbaldehydes and methoxypropadiene. Compared to the reported procedures, our approach is general, atom economic, highly selective, and the starting materials are easily available.

Graphical abstract: An efficient Au-catalyzed synthesis of isomukonidine, clausine L, mukonidine, glycosinine, mukonal, and clausine V from propadienyl methyl ether

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Article information

DOI
https://doi.org/10.1039/C2OB27432A
Article type
Paper
Submitted
20 Nov 2012
Accepted
19 Dec 2012
First published
20 Dec 2012

Org. Biomol. Chem., 2013,11, 1666-1671

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An efficient Au-catalyzed synthesis of isomukonidine, clausine L, mukonidine, glycosinine, mukonal, and clausine V from propadienyl methyl ether

Y. Qiu, D. Ma, C. Fu and S. Ma, Org. Biomol. Chem., 2013, 11, 1666 DOI: 10.1039/C2OB27432A

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