Issue 14, 2013
From the journal:

Organic & Biomolecular Chemistry

Fluoride as an inducible DNA cross-linking agent for new antitumor prodrug†

Jun Wu,a   Rong Huang,a   Tianlu Wang,a   Xi Zhao,a   Wanyi Zhang,a   Xiaocheng Weng,a   Tian Tiana  and  Xiang Zhou*ab  

* Corresponding authors

a College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, State Key Laboratory of Virology, Wuhan University, Hubei, Wuhan, P. R. of China
E-mail: xzhou@whu.edu.cn
Fax: +86-27-87336380
Tel: +86-27-61056559

b State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, P. R. of China

Abstract

Two new small compounds, which undergo fluoride-mediated self rearrangement, produce active DNA alkylating agent nitrogen mustard leading to DNA damage and finally cell death, providing potential antitumor prodrugs.

Graphical abstract: Fluoride as an inducible DNA cross-linking agent for new antitumor prodrug

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Article information

DOI
https://doi.org/10.1039/C2OB27324A
Article type
Paper
Submitted
29 Nov 2012
Accepted
03 Jan 2013
First published
04 Jan 2013

Org. Biomol. Chem., 2013,11, 2365-2369

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Fluoride as an inducible DNA cross-linking agent for new antitumor prodrug

J. Wu, R. Huang, T. Wang, X. Zhao, W. Zhang, X. Weng, T. Tian and X. Zhou, Org. Biomol. Chem., 2013, 11, 2365 DOI: 10.1039/C2OB27324A

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