Issue 8, 2013
From the journal:

Organic & Biomolecular Chemistry

Asymmetric Michael/cyclization tandem reaction of 4-hydroxycoumarin with β-nitroalkenes catalyzed by chiral bifunctional thioureas†

Ren-Qiang Mei,ab   Xiao-Ying Xu,a   Lin Peng,a   Fan Wang,ab   Fang Tiana  and  Li-Xin Wang*a  

* Corresponding authors

a Key Laboratory of Asymmetric Synthesis and Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, People's Republic of China
E-mail: wlxioc@cioc.ac.cn
Fax: +86-028-8525-5208

b Graduate University of Chinese Academy of Sciences, Beijing 10039, People's Republic of China

Abstract

The first asymmetric Michael/cyclization tandem reaction of 4-hydroxycoumarin with nitroolefins catalyzed by chiral bifunctional thioureas was reported and 2,3-dihydrofuro[3,2-c]-coumarin adducts have been obtained in moderate yields (53–75%) and good enantioselectivities (64–90% ee).

Graphical abstract: Asymmetric Michael/cyclization tandem reaction of 4-hydroxycoumarin with β-nitroalkenes catalyzed by chiral bifunctional thioureas

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Article information

DOI
https://doi.org/10.1039/C2OB27121D
Article type
Communication
Submitted
31 Oct 2012
Accepted
07 Jan 2013
First published
07 Jan 2013

Org. Biomol. Chem., 2013,11, 1286-1289

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Asymmetric Michael/cyclization tandem reaction of 4-hydroxycoumarin with β-nitroalkenes catalyzed by chiral bifunctional thioureas

R. Mei, X. Xu, L. Peng, F. Wang, F. Tian and L. Wang, Org. Biomol. Chem., 2013, 11, 1286 DOI: 10.1039/C2OB27121D

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