Issue 5, 2013

New 2,3-diaminopropionic acidinhibitors of AGE and ALE formation

Abstract

Novel 2,3-diaminopropionic acid-based molecules were synthesised and tested successfully as glyoxal/methylglyoxal scavengers and as AGE inhibitors. Addition of an 8-hydroxyquinoline moiety led to an increase of the overall activity. The compounds tested in this study were also proved to be efficient in trapping ALE precursor malondialdehyde.

Graphical abstract: New 2,3-diaminopropionic acid inhibitors of AGE and ALE formation

Article information

Article type
Paper
Submitted
25 Oct 2012
Accepted
30 Nov 2012
First published
03 Dec 2012

Org. Biomol. Chem., 2013,11, 773-780

New 2,3-diaminopropionic acid inhibitors of AGE and ALE formation

N. Audic, G. Potier and N. A. Sasaki, Org. Biomol. Chem., 2013, 11, 773 DOI: 10.1039/C2OB27084F

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