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Issue 11, 2013
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An expeditious synthesis of imatinib and analogues utilising flow chemistry methods

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Abstract

A flow-based route to imatinib, the API of Gleevec, was developed and the general procedure then used to generate a number of analogues which were screened for biological activity against Abl1. The flow synthesis required minimal manual intervention and was achieved despite the poor solubility of many of the reaction components.

Graphical abstract: An expeditious synthesis of imatinib and analogues utilising flow chemistry methods

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Publication details

The article was received on 15 Oct 2012, accepted on 04 Dec 2012 and first published on 05 Dec 2012


Article type: Paper
DOI: 10.1039/C2OB27002A
Citation: Org. Biomol. Chem., 2013,11, 1822-1839

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    An expeditious synthesis of imatinib and analogues utilising flow chemistry methods

    M. D. Hopkin, I. R. Baxendale and S. V. Ley, Org. Biomol. Chem., 2013, 11, 1822
    DOI: 10.1039/C2OB27002A

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