Issue 4, 2013
From the journal:

Organic & Biomolecular Chemistry

Thiol-inducible direct fluorescence monitoring of drug release†

Jun Wu,‡a   Rong Huang,‡a   Changcheng Wang,a   Wenting Liu,a   Jiaqi Wang,a   Xiaocheng Weng,a   Tian Tiana  and  Xiang Zhou*ab  

* Corresponding authors

a College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, State Key Laboratory of Virology, Wuhan University, Hubei, Wuhan, P. R. China
E-mail: xzhou@whu.edu.cn
Fax: +86-27-87336380
Tel: +86-27-61056559

b State Key Laboratory of Natural and Biomimetic Drugs, Beijing University, P. R. China

Abstract

A new bifunctional compound NCC, which undergoes thiol-mediated disulfide cleavage after cell entry, produces a red-shifted fluorescent emission in the cytosol and releases free active DNA alkylating agent CLB into the nucleus, and finally leads to DNA damage and cell death.

Graphical abstract: Thiol-inducible direct fluorescence monitoring of drug release

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Article information

DOI
https://doi.org/10.1039/C2OB26680F
Article type
Paper
Submitted
26 Aug 2012
Accepted
02 Nov 2012
First published
02 Nov 2012

Org. Biomol. Chem., 2013,11, 580-585

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Thiol-inducible direct fluorescence monitoring of drug release

J. Wu, R. Huang, C. Wang, W. Liu, J. Wang, X. Weng, T. Tian and X. Zhou, Org. Biomol. Chem., 2013, 11, 580 DOI: 10.1039/C2OB26680F

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