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Issue 7, 2013
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Iron oxide magnetic nanoparticles with versatile surface functions based on dopamine anchors

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Abstract

The synthesis of multifunctional magnetic nanoparticles (MF-MPs) is one of the most active research areas in advanced materials as their multifunctional surfaces allow conjugation of biological and chemical molecules, thus making it possible to achieve target-specific diagnostic in parallel to therapeutics. We report here a simple strategy to integrate in a one-step reaction several reactive sites onto the particles. The preparation of MF-MPs is based on their simultaneous modification with differently functionalized dopamine derivatives using simple solution chemistry. The formed MF-MPs show comparable magnetic properties to those of naked nanoparticles with almost unaltered particle size of around 25 nm. The different termini, amine, azide and maleimide functions, enable further functionalization of MF-MPs by the grafting-on approach. Michael addition, Cu(I) catalyzed « click » chemistry and amidation reactions are performed on the MF-MPs integrating subsequently 6-(ferrocenyl)-hexanethiol, horseradish peroxidase (HRP) and mannose.

Graphical abstract: Iron oxide magnetic nanoparticles with versatile surface functions based on dopamine anchors

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Publication details

The article was received on 06 Nov 2012, accepted on 02 Jan 2013 and first published on 09 Jan 2013


Article type: Paper
DOI: 10.1039/C3NR33506B
Citation: Nanoscale, 2013,5, 2692-2702
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    Iron oxide magnetic nanoparticles with versatile surface functions based on dopamine anchors

    M. Mazur, A. Barras, V. Kuncser, A. Galatanu, V. Zaitzev, K. V. Turcheniuk, P. Woisel, J. Lyskawa, W. Laure, A. Siriwardena, R. Boukherroub and S. Szunerits, Nanoscale, 2013, 5, 2692
    DOI: 10.1039/C3NR33506B

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