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Issue 21, 2013
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Plasmonic nanoprobes: from chemical sensing to medical diagnostics and therapy

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Abstract

This article provides an overview of the development and applications of plasmonics-active nanoprobes in our laboratory for chemical sensing, medical diagnostics and therapy. Molecular Sentinel nanoprobes provide a unique tool for DNA/RNA biomarker detection both in a homogeneous solution or on a chip platform for medical diagnostics. The possibility of combining spectral selectivity and high sensitivity of the surface-enhanced Raman scattering (SERS) process with the inherent molecular specificity of nanoprobes provides an important multiplex diagnostic modality. Gold nanostars can provide an excellent multi-modality platform, combining two-photon luminescence with photothermal therapy as well as Raman imaging with photodynamic therapy. Several examples of optical detection using SERS and photonics-based treatments are presented to illustrate the usefulness and potential of the plasmonic nanoprobes for theranostics, which seamlessly combines diagnostics and therapy.

Graphical abstract: Plasmonic nanoprobes: from chemical sensing to medical diagnostics and therapy

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Publication details

The article was received on 15 Jul 2013, accepted on 26 Aug 2013 and first published on 20 Sep 2013


Article type: Review Article
DOI: 10.1039/C3NR03633B
Citation: Nanoscale, 2013,5, 10127-10140
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    Plasmonic nanoprobes: from chemical sensing to medical diagnostics and therapy

    T. Vo-Dinh, A. M. Fales, G. D. Griffin, C. G. Khoury, Y. Liu, H. Ngo, S. J. Norton, J. K. Register, H. Wang and H. Yuan, Nanoscale, 2013, 5, 10127
    DOI: 10.1039/C3NR03633B

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