Issue 17, 2013

Gadolinium embedded iron oxide nanoclusters as T1T2 dual-modal MRI-visible vectors for safe and efficient siRNA delivery

Abstract

This report illustrates a new strategy of designing a T1T2 dual-modal magnetic resonance imaging (MRI)-visible vector for siRNA delivery and MRI. Hydrophobic gadolinium embedded iron oxide (GdIO) nanocrystals are self-assembled into nanoclusters in the water phase with the help of stearic acid modified low molecular weight polyethylenimine (stPEI). The resulting water-dispersible GdIO–stPEI nanoclusters possess good stability, monodispersity with narrow size distribution and competitive T1T2 dual-modal MR imaging properties. The nanocomposite system is capable of binding and delivering siRNA for knockdown of a gene of interest while maintaining its magnetic properties and biocompatibility. This new gadolinium embedded iron oxide nanocluster provides an important platform for safe and efficient gene delivery with non-invasive T1T2 dual-modal MRI monitoring capability.

Graphical abstract: Gadolinium embedded iron oxide nanoclusters as T1–T2 dual-modal MRI-visible vectors for safe and efficient siRNA delivery

Associated articles

Supplementary files

Article information

Article type
Paper
Submitted
29 May 2013
Accepted
19 Jun 2013
First published
26 Jun 2013

Nanoscale, 2013,5, 8098-8104

Gadolinium embedded iron oxide nanoclusters as T1T2 dual-modal MRI-visible vectors for safe and efficient siRNA delivery

X. Wang, Z. Zhou, Z. Wang, Y. Xue, Y. Zeng, J. Gao, L. Zhu, X. Zhang, G. Liu and X. Chen, Nanoscale, 2013, 5, 8098 DOI: 10.1039/C3NR02797J

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