Jump to main content
Jump to site search

Issue 18, 2013
Previous Article Next Article

Cellular interactions of doxorubicin-loaded DNA-modified halloysite nanotubes

Author affiliations

Abstract

Halloysite nanotube (HNT)-based supramolecular complexes are synthesized and evaluated with respect to their cytotoxicity and effects on cellular structures. As HNTs are water-insoluble, DNA is applied for wrapping the surface of HNTs to enhance their water-dispersibility. To investigate the potential of DNA-wrapped HNTs (HD) as a promising drug delivery carrier, doxorubicin (DOX) is introduced as a model anticancer agent and loaded onto HD. The DOX-loaded, DNA-wrapped HNTs (HDD) show sustained DOX release over two weeks without initial burst of DOX indicating delayed DOX release inside cells. In addition, effects of DNA-wrapped HNTs (HD) or HDD on the cytoskeleton organization of A549 cells are studied by visualizing the distribution of F-actin filaments using confocal laser scanning microscopy, and cellular morphological changes are observed by scanning electron microscopy and scanning ion conductance microscopy.

Graphical abstract: Cellular interactions of doxorubicin-loaded DNA-modified halloysite nanotubes

Back to tab navigation

Supplementary files

Publication details

The article was received on 22 May 2013, accepted on 02 Jul 2013 and first published on 29 Jul 2013


Article type: Paper
DOI: 10.1039/C3NR02665E
Citation: Nanoscale, 2013,5, 8577-8585
  •   Request permissions

    Cellular interactions of doxorubicin-loaded DNA-modified halloysite nanotubes

    Y. Lee, G. Jung, S. J. Cho, K. E. Geckeler and H. Fuchs, Nanoscale, 2013, 5, 8577
    DOI: 10.1039/C3NR02665E

Search articles by author

Spotlight

Advertisements