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Issue 18, 2013
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Cellular interactions of doxorubicin-loaded DNA-modified halloysite nanotubes

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Halloysite nanotube (HNT)-based supramolecular complexes are synthesized and evaluated with respect to their cytotoxicity and effects on cellular structures. As HNTs are water-insoluble, DNA is applied for wrapping the surface of HNTs to enhance their water-dispersibility. To investigate the potential of DNA-wrapped HNTs (HD) as a promising drug delivery carrier, doxorubicin (DOX) is introduced as a model anticancer agent and loaded onto HD. The DOX-loaded, DNA-wrapped HNTs (HDD) show sustained DOX release over two weeks without initial burst of DOX indicating delayed DOX release inside cells. In addition, effects of DNA-wrapped HNTs (HD) or HDD on the cytoskeleton organization of A549 cells are studied by visualizing the distribution of F-actin filaments using confocal laser scanning microscopy, and cellular morphological changes are observed by scanning electron microscopy and scanning ion conductance microscopy.

Graphical abstract: Cellular interactions of doxorubicin-loaded DNA-modified halloysite nanotubes

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Publication details

The article was received on 22 May 2013, accepted on 02 Jul 2013 and first published on 29 Jul 2013

Article type: Paper
DOI: 10.1039/C3NR02665E
Nanoscale, 2013,5, 8577-8585

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    Cellular interactions of doxorubicin-loaded DNA-modified halloysite nanotubes

    Y. Lee, G. Jung, S. J. Cho, K. E. Geckeler and H. Fuchs, Nanoscale, 2013, 5, 8577
    DOI: 10.1039/C3NR02665E

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