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Issue 15, 2013
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Lipogels: surface-adherent composite hydrogels assembled from poly(vinyl alcohol) and liposomes

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Abstract

Drug-eluting engineered surface coatings are of paramount importance for many biomedical applications from implantable devices to tissue engineering. Herein, we present the assembly of lipogels, composite physical hydrogels assembled from poly(vinyl alcohol) and liposomes using thiol-disulfide exchange between end group modified PVA and thiocholesterol containing liposomes, and the response of adhering cells to these coatings. We demonstrate the controlled loading of liposomes into the polymer matrix and the preserved mechanical properties of the lipogels. Furthermore, the lipogels are successfully rendered cell adhesive by incorporation of poly(L-lysine) into the PVA polymer matrix or by poly(dopamine) coating of the lipogels. The successful lipid uptake from the lipogels by macrophages, hepatocytes, and myoblasts was monitored by flow cytometry. Finally, the delivery of active cargo, paclitaxel, to adherent myoblasts is shown, thus illustrating the potential of the lipogels as a drug eluting interface for biomedical applications.

Graphical abstract: Lipogels: surface-adherent composite hydrogels assembled from poly(vinyl alcohol) and liposomes

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Publication details

The article was received on 03 Apr 2013, accepted on 19 Apr 2013 and first published on 23 Apr 2013


Article type: Paper
DOI: 10.1039/C3NR01662E
Citation: Nanoscale, 2013,5, 6758-6766
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    Lipogels: surface-adherent composite hydrogels assembled from poly(vinyl alcohol) and liposomes

    B. E. B. Jensen, L. Hosta-Rigau, P. R. Spycher, E. Reimhult, B. Städler and A. N. Zelikin, Nanoscale, 2013, 5, 6758
    DOI: 10.1039/C3NR01662E

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