Issue 7, 2013
From the journal:

Nanoscale

‘Marker-of-self’ functionalization of nanoscale particles through a top-down cellular membrane coating approach†

Che-Ming J. Hu,ab   Ronnie H. Fang,ab   Brian T. Luk,bc   Kevin N. H. Chen,a   Cody Carpenter,a   Weiwei Gao,ab   Kang Zhangade  and  Liangfang Zhang*ab  

* Corresponding authors

a Department of NanoEngineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
E-mail: zhang@ucsd.edu
Tel: +1-858-246-0999

b Moores Cancer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA

c Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA

d Department of Ophthalmology and Shiley Eye Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA

e State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510275, China

Abstract

We investigate the ‘marker-of-self’ functionalization of nanoparticles through coating of natural RBC membranes. The membrane translocation approach is shown to be highly efficient and bestows nanoparticles with correctly oriented and functional immunomodulatory proteins such as CD47 at equivalent density to natural RBCs.

Graphical abstract: ‘Marker-of-self’ functionalization of nanoscale particles through a top-down cellular membrane coating approach

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Article information

DOI
https://doi.org/10.1039/C3NR00015J
Article type
Communication
Submitted
02 Jan 2013
Accepted
22 Feb 2013
First published
25 Feb 2013

Nanoscale, 2013,5, 2664-2668

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‘Marker-of-self’ functionalization of nanoscale particles through a top-down cellular membrane coating approach

C. J. Hu, R. H. Fang, B. T. Luk, K. N. H. Chen, C. Carpenter, W. Gao, K. Zhang and L. Zhang, Nanoscale, 2013, 5, 2664 DOI: 10.1039/C3NR00015J

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