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Issue 24, 2013
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Biophotonic logic devices based on quantum dots and temporally-staggered Förster energy transfer relays

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Abstract

Integrating photonic inputs/outputs into unimolecular logic devices can provide significantly increased functional complexity and the ability to expand the repertoire of available operations. Here, we build upon a system previously utilized for biosensing to assemble and prototype several increasingly sophisticated biophotonic logic devices that function based upon multistep Förster resonance energy transfer (FRET) relays. The core system combines a central semiconductor quantum dot (QD) nanoplatform with a long-lifetime Tb complex FRET donor and a near-IR organic fluorophore acceptor; the latter acts as two unique inputs for the QD-based device. The Tb complex allows for a form of temporal memory by providing unique access to a time-delayed modality as an alternate output which significantly increases the inherent computing options. Altering the device by controlling the configuration parameters with biologically based self-assembly provides input control while monitoring changes in emission output of all participants, in both a spectral and temporal-dependent manner, gives rise to two input, single output Boolean Logic operations including OR, AND, INHIBIT, XOR, NOR, NAND, along with the possibility of gate transitions. Incorporation of an enzymatic cleavage step provides for a set-reset function that can be implemented repeatedly with the same building blocks and is demonstrated with single input, single output YES and NOT gates. Potential applications for these devices are discussed in the context of their constituent parts and the richness of available signal.

Graphical abstract: Biophotonic logic devices based on quantum dots and temporally-staggered Förster energy transfer relays

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Publication details

The article was received on 16 Jul 2013, accepted on 19 Aug 2013 and first published on 18 Sep 2013


Article type: Paper
DOI: 10.1039/C3NR03655C
Citation: Nanoscale, 2013,5, 12156-12170

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    Biophotonic logic devices based on quantum dots and temporally-staggered Förster energy transfer relays

    J. C. Claussen, W. R. Algar, N. Hildebrandt, K. Susumu, M. G. Ancona and I. L. Medintz, Nanoscale, 2013, 5, 12156
    DOI: 10.1039/C3NR03655C

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