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Issue 19, 2013
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Lipid-insertion enables targeting functionalization of erythrocyte membrane-cloaked nanoparticles

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Abstract

RBC membrane-cloaked polymeric nanoparticles represent an emerging nanocarrier platform with extended circulation in vivo. A lipid-insertion method is employed to functionalize these nanoparticles without the need for direct chemical conjugation. Insertion of both folate and the nucleolin-targeting aptamer AS1411 shows receptor-specific targeting against model cancer cell lines.

Graphical abstract: Lipid-insertion enables targeting functionalization of erythrocyte membrane-cloaked nanoparticles

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Supplementary files

Article information


Submitted
14 Jun 2013
Accepted
17 Jul 2013
First published
19 Jul 2013

This article is Open Access

Nanoscale, 2013,5, 8884-8888
Article type
Communication

Lipid-insertion enables targeting functionalization of erythrocyte membrane-cloaked nanoparticles

R. H. Fang, C. J. Hu, K. N. H. Chen, B. T. Luk, C. W. Carpenter, W. Gao, S. Li, D. Zhang, W. Lu and L. Zhang, Nanoscale, 2013, 5, 8884
DOI: 10.1039/C3NR03064D

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