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Issue 9, 2013
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From micrograms to grams: scale-up synthesis of eribulin mesylate

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Abstract

Covering: 1993 to 2002

The synthesis of eribulin mesylate from microgram to multi-gram scale is described in this Highlight. Key coupling reactions include formation of the C30a to C1 carbon–carbon bond and macrocyclic ring closure through an intramolecular Nozaki–Hiyama–Kishi reaction.

Graphical abstract: From micrograms to grams: scale-up synthesis of eribulin mesylate

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Article information


Submitted
30 May 2013
First published
30 Jul 2013

Nat. Prod. Rep., 2013,30, 1158-1164
Article type
Highlight

From micrograms to grams: scale-up synthesis of eribulin mesylate

M. J. Yu, W. Zheng and B. M. Seletsky, Nat. Prod. Rep., 2013, 30, 1158
DOI: 10.1039/C3NP70051H

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