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Issue 12, 2013
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History, biology and chemistry of Mycobacterium ulcerans infections (Buruli ulcer disease)

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Abstract

Covering: up to the end of July 2013

Mycobacterium ulcerans infections (Buruli ulcer disease) have a long history that can be traced back 150 years. The successive discoveries of the mycobacteria in 1948 and of mycolactone A/B in 1999, the toxin responsible for this dramatic necrotic skin disease, resulted in a paradigm shift concerning the disease itself and in a broader sense, delineated an entirely new role for bioactive polyketides as virulence factors. The fascinating history, biology and chemistry of M. ulcerans infections are discussed in this review.

Graphical abstract: History, biology and chemistry of Mycobacterium ulcerans infections (Buruli ulcer disease)

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Submitted
19 Jul 2013
First published
01 Nov 2013

Nat. Prod. Rep., 2013,30, 1527-1567
Article type
Review Article

History, biology and chemistry of Mycobacterium ulcerans infections (Buruli ulcer disease)

A. Chany, C. Tresse, V. Casarotto and N. Blanchard, Nat. Prod. Rep., 2013, 30, 1527
DOI: 10.1039/C3NP70068B

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