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Issue 3, 2013
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A genomic approach to the cryptic secondary metabolome of the anaerobic world

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Abstract

Covering: up to September 2012.

A total of 211 complete and published genomes from anaerobic bacteria are analysed for the presence of secondary metabolite biosynthesis gene clusters, in particular those tentatively coding for polyketide synthases (PKS) and non-ribosomal peptide synthetases (NRPS). We investigate the distribution of these gene clusters according to bacterial phylogeny and, if known, correlate these to the type of metabolic pathways they encode. The potential of anaerobes as secondary metabolite producers is highlighted.

Graphical abstract: A genomic approach to the cryptic secondary metabolome of the anaerobic world

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Publication details

The article was received on 18 Oct 2012 and first published on 21 Dec 2012


Article type: Review Article
DOI: 10.1039/C2NP20103H
Nat. Prod. Rep., 2013,30, 392-428

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    A genomic approach to the cryptic secondary metabolome of the anaerobic world

    A. Letzel, S. J. Pidot and C. Hertweck, Nat. Prod. Rep., 2013, 30, 392
    DOI: 10.1039/C2NP20103H

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