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Issue 11, 2013
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Dendrimers as macromolecular tools to tackle from colon to brain tumor types: a concise overview

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Abstract

It is well documented that dendrimers were described as one of the most tunable nanomaterials both for therapeutic applications and diagnostics. This concise review surveys the different types of both non-targeted and targeted drug-encapsulated dendrimers and dendrimer–drug conjugates in oncology. In addition, progress in biocompatible dendritic architectures is discussed as it relates to the development of anti-cancer agents through in vitro and in vivo studies. In particular, we present relevant examples of these nanodevices to treat aggressive cancers such as colon and brain tumors. This review concludes with a brief survey of perspectives for clinical translation.

Graphical abstract: Dendrimers as macromolecular tools to tackle from colon to brain tumor types: a concise overview

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Publication details

The article was received on 21 Mar 2013, accepted on 15 May 2013 and first published on 22 May 2013


Article type: Perspective
DOI: 10.1039/C3NJ00300K
Citation: New J. Chem., 2013,37, 3337-3357
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    Dendrimers as macromolecular tools to tackle from colon to brain tumor types: a concise overview

    S. Mignani and J. Majoral, New J. Chem., 2013, 37, 3337
    DOI: 10.1039/C3NJ00300K

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