Synthesis and structure–activity relationship of benzylamine supported platinum(iv) complexes

Abstract

A series of benzylamine derivative (BAD) supported platinum(IV) complexes (PtCl₄(BADs)₂) have been synthesized. The complexes were tested in vitro against the MCF-7 cell line, and the 4-fluoro and 4-chloro containing complexes expressed impressive anticancer activities. Their DNA binding nature for a structure–activity relationship (SAR) study was investigated with physicochemical-indicators (PCI) which categorized them as good intercalators for host–guest chemistry. A mechanism for drug efficacy is proposed by analysis of the resultant viscosity and surface tension of PtCl₄(BADs)₂–DNA solutions named as the drug-friccohesity interaction (DFI). The complexes have shown significant antioxidant activity, determined on the basis of free radical scavenging effects due to their terminating action against the reactive species.