Issue 2, 2013
From the journal:

New Journal of Chemistry

Synthesis of multi-antigenic platforms as vaccine candidates against cancers†

Michele Fiore,a   Baptiste Thomas,a   Vincent Duléry,a   Pascal Dumya  and  Olivier Renaudet*ab  

* Corresponding authors

a Département de Chimie Moléculaire, UMR-CNRS 5250 & ICMG FR 2607, Université Joseph Fourier, BP 53, 570 rue de la chimie, 38041 Grenoble Cedex 9, France
E-mail: olivier.renaudet@ujf-grenoble.fr
Fax: +33 4 56 52 08 03
Tel: +33 4 56 52 08 33

b Institut Universitaire de France, 103 boulevard Saint-Michel, 75005 Paris, France

Abstract

Cancer cells are characterized by the presence of diverse antigens on their surface. The combination of these structures in a single molecule represents an attractive strategy to obtain vaccine candidates with improved immunological properties. Herein we report the synthesis of a mixture of heterotopic platforms bearing the Tn and TF carbohydrate antigens and an immunostimulating poliovirus peptide.

Graphical abstract: Synthesis of multi-antigenic platforms as vaccine candidates against cancers

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Article information

DOI
https://doi.org/10.1039/C2NJ40972K
Article type
Letter
Submitted
12 Sep 2012
Accepted
21 Nov 2012
First published
23 Nov 2012

New J. Chem., 2013,37, 286-289

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Synthesis of multi-antigenic platforms as vaccine candidates against cancers

M. Fiore, B. Thomas, V. Duléry, P. Dumy and O. Renaudet, New J. Chem., 2013, 37, 286 DOI: 10.1039/C2NJ40972K

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