Since no chelating agent has been clinically approved for the treatment of Cd2+ intoxicated humans, we have previously investigated diethylenetriaminepentaacetic acid (Na5DTPA) to abstract this toxic metal from plasma proteins in vitro. In addition to the complete mobilization of Cd2+, an inadvertent abstraction of Zn2+ from metalloproteins was also observed. Therefore, we have evaluated the effect of ZnNa3DTPA on the plasma distribution of Ca, Cd, Cu, Fe and Zn after its addition to Cd2+-spiked rabbit plasma. ZnNa3DTPA was as efficient as Na5DTPA in abstracting Cd2+ (100% removal), but it did not abstract Zn2+. Thus, complexes between essential metals (e.g. Zn2+) and known chelating agents emerge as feasible candidates to decrease potential adverse side effects in patients.
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