Jump to main content
Jump to site search

Issue 10, 2013
Previous Article Next Article

Microwave-assisted synthesis of N-heterocycles in medicinal chemistry

Author affiliations

Abstract

The syntheses of almost all N-heterocycles have now been successfully performed under microwave irradiation and have provided significant improvements in the reaction time and efficiency. The peculiar properties of dielectric heating give it the ability to strongly promote cyclocondensation, cycloaddition and selective N-heterocycle functionalisation and it has, therefore, very much caught the attention of the medicinal chemistry community. In this work, we present an overview of recent literature and technical advances in this research field with the aim of providing insight into the applications of microwave-assisted synthesis in the preparation of the main drug categories that contain N-heterocycle scaffolds.

Graphical abstract: Microwave-assisted synthesis of N-heterocycles in medicinal chemistry

Back to tab navigation

Publication details

The article was received on 02 Jun 2013, accepted on 07 Aug 2013 and first published on 08 Aug 2013


Article type: Review Article
DOI: 10.1039/C3MD00152K
Citation: Med. Chem. Commun., 2013,4, 1323-1343

  •   Request permissions

    Microwave-assisted synthesis of N-heterocycles in medicinal chemistry

    D. Garella, E. Borretto, A. Di Stilo, K. Martina, G. Cravotto and P. Cintas, Med. Chem. Commun., 2013, 4, 1323
    DOI: 10.1039/C3MD00152K

Search articles by author

Spotlight

Advertisements