Issue 8, 2013

Chemical motifs that redox cycle and their associated toxicity

Abstract

Focussed screening of known redox cyclers, and structurally related compounds, was performed using a horseradish peroxidase–phenol red (hydrogen peroxide) assay. A cell viability assay was then used to further understand structure-based toxicity. Pyrimidotriazinediones were confirmed as structural alerts and new redox cycling motifs were identified.

Graphical abstract: Chemical motifs that redox cycle and their associated toxicity

Supplementary files

Article information

Article type
Concise Article
Submitted
29 May 2013
Accepted
29 Jun 2013
First published
01 Jul 2013

Med. Chem. Commun., 2013,4, 1175-1180

Chemical motifs that redox cycle and their associated toxicity

P. Rana, R. Naven, A. Narayanan, Y. Will and L. H. Jones, Med. Chem. Commun., 2013, 4, 1175 DOI: 10.1039/C3MD00149K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements