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Issue 6, 2013
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Targeted cancer cell inhibition using multifunctional dendrimer-entrapped gold nanoparticles

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Abstract

Generation 5-poly(amidoamine) dendrimers pre-modified with folic acid and methotrexate (G5-FA-MTX) were used as templates for the synthesis of dendrimer-entrapped gold nanoparticles (Au DENPs). The synthesized [(Au0)50-G5-FA-MTX] DENPs were able to target and specifically inhibit the growth of cancer cells overexpressing high affinity folic acid receptors.

Graphical abstract: Targeted cancer cell inhibition using multifunctional dendrimer-entrapped gold nanoparticles

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Supplementary files

Article information


Submitted
13 Feb 2013
Accepted
25 Apr 2013
First published
26 Apr 2013

Med. Chem. Commun., 2013,4, 1001-1005
Article type
Concise Article

Targeted cancer cell inhibition using multifunctional dendrimer-entrapped gold nanoparticles

L. Zheng, J. Zhu, M. Shen, X. Chen, J. R. Baker, S. H. Wang, G. Zhang and X. Shi, Med. Chem. Commun., 2013, 4, 1001
DOI: 10.1039/C3MD00050H

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