Issue 12, 2013
From the journal:

MedChemComm

Ketorolac beats ketoprofen: lower photodecarboxylation, photohemolysis and phototoxicity†

Christopher D. McTiernan,a   Chiara Fasciani,a   Maria González-Béjar,b   Daniel Roca-Sanjuán,b   Emilio I. Alarcon*a  and  Jose Carlos Netto-Ferreira*ac  

* Corresponding authors

a Department of Chemistry and Centre for Catalysis Research and Innovation, University of Ottawa, 10 Marie Curie, Ottawa K1N 6N5, Canada
E-mail: emilio@photo.chem.uottawa.ca, josecarlos@photo.chem.uottawa.ca

b Instituto de Ciencia Molecular, Universidad de Valencia, C/Catedrático José Beltrán, 2, Paterna, Valencia, Spain

c Departamento de Química, Universidade Federal Rural do Rio de Janeiro, Seropédica, Rio de Janeiro, Brazil

Abstract

Ketorolac shows reduced photohemolytic activity and low phototoxicity against human skin fibroblasts when compared to ketoprofen. The low decarboxylation quantum yield together with the efficient non-radiative deactivation of the triplet and singlet excited states of ketorolac are believed to be responsible for this behaviour.

Graphical abstract: Ketorolac beats ketoprofen: lower photodecarboxylation, photohemolysis and phototoxicity

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C3MD00258F
Article type
Concise Article
Submitted
10 Sep 2013
Accepted
16 Oct 2013
First published
22 Oct 2013

Med. Chem. Commun., 2013,4, 1619-1622

Permissions

Request permissions

Ketorolac beats ketoprofen: lower photodecarboxylation, photohemolysis and phototoxicity

C. D. McTiernan, C. Fasciani, M. González-Béjar, D. Roca-Sanjuán, E. I. Alarcon and J. C. Netto-Ferreira, Med. Chem. Commun., 2013, 4, 1619 DOI: 10.1039/C3MD00258F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements