Development of a diketopiperazine-forming dipeptidyl Gly-Pro spacer for preparation of an antibody–drug conjugate†
Abstract
We developed a novel diketopiperazine-forming dipeptidyl spacer aimed at application in antibody–
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* Corresponding authors
a
RIKEN, Advanced Science Institute, Synthetic Cellular Chemistry Laboratory, Hirosawa, Wako, Saitama 351-0198, Japan
E-mail:
smanabe@riken.jp
Fax: +81 48 462 4680
Tel: +81 48 467 9432
b
Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba 277-0882, Japan
E-mail:
yhmatsum@east.ncc.go.jp
Fax: +81 4713 6857
Tel: +81 4713 6857
We developed a novel diketopiperazine-forming dipeptidyl spacer aimed at application in antibody–
S. Manabe, H. Machida, Y. Aihara, M. Yasunaga, Y. Ito and Y. Matsumura, Med. Chem. Commun., 2013, 4, 792 DOI: 10.1039/C3MD00075C
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