Issue 1, 2013
From the journal:

MedChemComm

Two-in-one: a pH-sensitive, acridine-based, fluorescent probe binds G-quadruplexes in oncogene promoters†

Claudia Percivalle,ab   Tariq Mahmood‡a  and  Sylvain Ladame*a  

* Corresponding authors

a Department of Bioengineering, Imperial College London, South Kensington campus, London SW7 2AZ, UK
E-mail: sladame@imperial.ac.uk
Fax: +44 (0)02075949817
Tel: +44 (0)02075945308

b Department of Chemistry, University of Pavia, 27100 Pavia, Italy

Abstract

We report the synthesis of an acridine-containing cyanine dye and demonstrate its potential as a pH-responsive colorimetric indicator and fluorescent probe. Similarly to its parent molecule BRACO-19, this tri-substituted acridine also binds strongly to DNA quadruplexes found in the promoter region of oncogenes.

Graphical abstract: Two-in-one: a pH-sensitive, acridine -based, fluorescent probe binds G-quadruplexes in oncogene promoters

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Article information

DOI
https://doi.org/10.1039/C2MD20173A
Article type
Concise Article
Submitted
29 Jun 2012
Accepted
06 Sep 2012
First published
11 Sep 2012

Med. Chem. Commun., 2013,4, 211-215

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Two-in-one: a pH-sensitive, acridine-based, fluorescent probe binds G-quadruplexes in oncogene promoters

C. Percivalle, T. Mahmood and S. Ladame, Med. Chem. Commun., 2013, 4, 211 DOI: 10.1039/C2MD20173A

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