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Issue 1, 2013
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On the importance of synthetic organic chemistry in drug discovery: reflections on the discovery of antidiabetic agent ertugliflozin§

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Abstract

The discovery of antidiabetic agent ertugliflozin is described. The compound belongs to a new class of SGLT2 inhibitors bearing a dioxa-bicyclo[3.2.1]octane motif. This article describes the critical role that organic synthesis played in both influencing our medicinal chemistry strategy and speeding up the progression of our program.

Graphical abstract: On the importance of synthetic organic chemistry in drug discovery: reflections on the discovery of antidiabetic agent ertugliflozin

  • This article is part of the themed collection: New Talent
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Publication details

The article was received on 24 Jun 2012, accepted on 11 Jul 2012 and first published on 16 Jul 2012


Article type: Concise Article
DOI: 10.1039/C2MD20163A
Med. Chem. Commun., 2013,4, 101-111

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    On the importance of synthetic organic chemistry in drug discovery: reflections on the discovery of antidiabetic agent ertugliflozin

    V. Mascitti, B. A. Thuma, A. C. Smith, R. P. Robinson, T. Brandt, A. S. Kalgutkar, T. S. Maurer, B. Samas and R. Sharma, Med. Chem. Commun., 2013, 4, 101
    DOI: 10.1039/C2MD20163A

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