Issue 10, 2013
From the journal:

Molecular BioSystems

Modeling, design and synthesis of new heteroaryl ethylenes active against the MCF-7 breast cancer cell-line†

Vincenza Barresi,*a   Carmela Bonaccorso,b   Giuseppe Consiglio,c   Laura Goracci,*b   Nicolò Musso,a   Giuseppe Musumarra,b   Cristina Satrianob  and  Cosimo G. Fortuna*b  

* Corresponding authors

a Sezione di Biochimica, Dipartimento di Scienze Bio-Mediche, Università degli Studi di Catania, Viale A. Doria 6, Catania, Italy
E-mail: barregi@unict.it
Fax: +39 0957384256
Tel: +39 0957384223

b Dipartimento di Scienze Chimiche, Università degli Studi di Catania, Viale A. Doria 6, Catania, Italy
E-mail: cg.fortuna@unict.it, laura.goracci@gmail.com
Fax: +39 095580138
Tel: +39 0957385010

c Dipartimento di Ingegneria Industriale e Meccanica, Università degli Studi di Catania, Viale A. Doria 6, Catania, Italy

Abstract

A dataset of 50 compounds was used to generate a QSAR model and to design 9 new heteroaryl ethylenes. These compounds were synthesized, tested in vitro and a significant agreement with in silico predictions observed. Studies using Laser Scanning Confocal Microscopy pointed out that the compounds may act by different mechanisms.

Graphical abstract: Modeling, design and synthesis of new heteroaryl ethylenes active against the MCF-7 breast cancer cell-line

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Article information

DOI
https://doi.org/10.1039/C3MB70151D
Article type
Communication
Submitted
11 Apr 2013
Accepted
04 Jul 2013
First published
04 Jul 2013

Mol. BioSyst., 2013,9, 2426-2429

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Modeling, design and synthesis of new heteroaryl ethylenes active against the MCF-7 breast cancer cell-line

V. Barresi, C. Bonaccorso, G. Consiglio, L. Goracci, N. Musso, G. Musumarra, C. Satriano and C. G. Fortuna, Mol. BioSyst., 2013, 9, 2426 DOI: 10.1039/C3MB70151D

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