Issue 5, 2013
From the journal:

Molecular BioSystems

Mutational biosynthesis of a FK506 analogue containing a non-natural starter unit†

Yeon Hee Ban,‡a   Jong Hyun Lee,‡b   Gyo Rim Gu,a   Boram Lee,c   SangJoon Mo,a   Ho Jeong Kwonc  and  Yeo Joon Yoon*a  

* Corresponding authors

a Department of Chemistry and Nano Science, Ewha Womans University, Seoul 120-750, Republic of Korea
E-mail: joonyoon@ewha.ac.kr
Fax: +82-2-3277-3419
Tel: +82-2-3277-4082

b College of Pharmacy, Dongduk Women's University, Seoul 136-714, Republic of Korea

c Department of Biotechnology, The Translational Research Center for Protein Function Control, Yonsei University, Seoul 120-746, Republic of Korea

Abstract

A FK506 analogue containing a non-natural starter unit was obtained through mutasynthesis by feeding cultures of Streptomyces sp. KCTC 11604BP fkbO deletion mutant with 3-cyclohexene-1-carboxylic acid. The structure of the new compound, 32-dehydroxy-FK506, and its biological activities were determined.

Graphical abstract: Mutational biosynthesis of a FK506 analogue containing a non-natural starter unit

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Article information

DOI
https://doi.org/10.1039/C2MB25419K
Article type
Communication
Submitted
08 Oct 2012
Accepted
27 Nov 2012
First published
28 Nov 2012

Mol. BioSyst., 2013,9, 944-947

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Mutational biosynthesis of a FK506 analogue containing a non-natural starter unit

Y. H. Ban, J. H. Lee, G. R. Gu, B. Lee, S. Mo, H. J. Kwon and Y. J. Yoon, Mol. BioSyst., 2013, 9, 944 DOI: 10.1039/C2MB25419K

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