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Issue 5, 2013
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Chemical biology based on target-selective degradation of proteins and carbohydrates using light-activatable organic molecules

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Abstract

Proteins and carbohydrates play crucial roles in a wide range of biological processes, including serious diseases. The development of novel and innovative methods for selective control of specific proteins and carbohydrates functions has attracted much attention in the field of chemical biology. In this account article, the development of novel chemical tools, which can degrade target proteins and carbohydrates by irradiation with a specific wavelength of light under mild conditions without any additives, is introduced. This novel class of photochemical agents promise bright prospects for finding not only molecular-targeted bioprobes for understanding of the structure–activity relationships of proteins and carbohydrates but also novel therapeutic drugs targeting proteins and carbohydrates.

Graphical abstract: Chemical biology based on target-selective degradation of proteins and carbohydrates using light-activatable organic molecules

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Publication details

The article was received on 06 Oct 2012, accepted on 30 Nov 2012 and first published on 30 Nov 2012


Article type: Review Article
DOI: 10.1039/C2MB25416F
Mol. BioSyst., 2013,9, 834-854

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    Chemical biology based on target-selective degradation of proteins and carbohydrates using light-activatable organic molecules

    K. Toshima, Mol. BioSyst., 2013, 9, 834
    DOI: 10.1039/C2MB25416F

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