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Issue 5, 2013
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Tissue specific delivery of estrone-conjugated siRNAs

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Abstract

An estrone phosphoramidite, synthesized in a single step, was directly incorporated at the 5′ ends of small interfering RNAs (siRNAs). The resulting estrone-conjugated siRNAs readily pass through cellular membranes and down-regulate the target protein, and show specific distributions in vivo.

Graphical abstract: Tissue specific delivery of estrone-conjugated siRNAs

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Supplementary files

Article information


Submitted
29 Jun 2012
Accepted
05 Sep 2012
First published
06 Sep 2012

Mol. BioSyst., 2013,9, 974-977
Article type
Paper

Tissue specific delivery of estrone-conjugated siRNAs

E. Bang, E. M. Jeon, W. Kim, K. Lee, K. Kim and B. H. Kim, Mol. BioSyst., 2013, 9, 974
DOI: 10.1039/C2MB25258A

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