Tissue specific delivery of estrone-conjugated siRNAs†
Abstract
An estrone phosphoramidite, synthesized in a single step, was directly incorporated at the 5′ ends of small interfering RNAs (siRNAs). The resulting estrone-conjugated siRNAs readily pass through cellular membranes and down-regulate the target
- This article is part of the themed collection: Molecular Biosystems Chemical Biology in Asia