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Issue 5, 2013
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Rapid and specific electrochemical detection of prostate cancer cells using an aperture sensor array

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Abstract

A rapid, simple and specific cancer cell counting sensor would allow for early detection and better disease management. We have developed a novel cell counting device that can specifically count 125 prostate cancer cells in both complex media with serum and a mixed cell population containing non-target cells within 15 min. The microfabricated glass chip with exposed gold apertures utilizes the anti-EpCAM antibody to selectively count prostate cancer cells via differential pulse voltammetry. The newly developed sensor exhibits excellent sensitivity and selectivity. The cells remain viable throughout the counting process and can be used for further analysis. This device could have utility for future applications in early stage cancer diagnosis.

Graphical abstract: Rapid and specific electrochemical detection of prostate cancer cells using an aperture sensor array

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Publication details

The article was received on 14 Sep 2012, accepted on 21 Dec 2012 and first published on 03 Jan 2013


Article type: Paper
DOI: 10.1039/C2LC41049D
Citation: Lab Chip, 2013,13, 940-946
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    Rapid and specific electrochemical detection of prostate cancer cells using an aperture sensor array

    M. Moscovici, A. Bhimji and S. O. Kelley, Lab Chip, 2013, 13, 940
    DOI: 10.1039/C2LC41049D

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