Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 24, 2013
Previous Article Next Article

Elastomeric microvalves as tunable nanochannels for concentration polarization

Author affiliations

Abstract

Elastomeric microvalves in poly(dimethylsiloxane) (PDMS) devices are today's paradigm for massively parallel microfluidic operations. Here, we report that such valves can act as nanochannels upon closure. When tuning nanospace heights between ~55 nm and ~7 nm, the nanofluidic phenomenon of concentration polarization could be induced. A wide range of concentration polarization regimes (anodic and cathodic analyte focusing and stacking) was achieved simply by valve pressure actuation. Electro-osmotic flow generated a counterpressure which also could be used to actuate between concentration polarization regimes. 1000-fold preconcentration of fluorescein was achieved in just 100 s in the anodic focusing regime. After valve opening, a concentrated sample plug could be transported through the valve, though at the cost of some defocusing. Reversible nanochannels open new avenues for integrating electrokinetic operations and assays in large scale integrated microfluidics.

Graphical abstract: Elastomeric microvalves as tunable nanochannels for concentration polarization

Back to tab navigation

Article information


Submitted
30 May 2013
Accepted
30 Sep 2013
First published
24 Oct 2013

Lab Chip, 2013,13, 4810-4815
Article type
Paper

Elastomeric microvalves as tunable nanochannels for concentration polarization

J. Quist, S. J. Trietsch, P. Vulto and T. Hankemeier, Lab Chip, 2013, 13, 4810
DOI: 10.1039/C3LC50658D

Social activity

Search articles by author

Spotlight

Advertisements