Issue 17, 2013

Micro-scale blood plasma separation: from acoustophoresis to egg-beaters


Plasma is a rich mine of various biomarkers including proteins, metabolites and circulating nucleic acids. The diagnostic and therapeutic potential of these analytes has been quite recently uncovered, and the number of plasma biomarkers will still be growing in the coming years. A significant part of the blood plasma preparation is still handled manually, off-chip, via centrifugation or filtration. These batch methods have variable waiting times, and are often performed under non-reproducible conditions that may impair the collection of analytes of interest, with variable degradation. The development of miniaturised modules capable of automated and reproducible blood plasma separation would aid in the translation of lab-on-a-chip devices to the clinical market. Here we propose a systematic review of major plasma analytes and target applications, alongside existing solutions for micro-scale blood plasma extraction, focusing on the approaches that have been biologically validated for specific applications.

Graphical abstract: Micro-scale blood plasma separation: from acoustophoresis to egg-beaters

Article information

Article type
Critical Review
06 Apr 2013
23 May 2013
First published
04 Jul 2013
This article is Open Access
Creative Commons BY license

Lab Chip, 2013,13, 3323-3346

Micro-scale blood plasma separation: from acoustophoresis to egg-beaters

M. Kersaudy-Kerhoas and E. Sollier, Lab Chip, 2013, 13, 3323 DOI: 10.1039/C3LC50432H

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