Issue 7, 2013
From the journal:

Lab on a Chip

A biopharmaceutical plant on a chip: continuous micro-devices for the production of monoclonal antibodies†

Lucía D. Garza-García,a   Leydi M. Carrillo-Cocom,a   Diana Araiz-Hernández,a   Pedro Soto-Vázquez,a   Julián López-Meza,a   Eduardo J. Tapia-Mejía,b   Sergio Camacho-León,b   Erika García-López,c   Ciro A. Rodríguez-Gonzálezc  and  Mario M. Alvarez*a  

* Corresponding authors

a Tecnológico de Monterrey at Monterrey, Centro de Biotecnología-FEMSA, Ave. Eugenio Garza-Sada 2501, Monterrey, N.L., México
E-mail: Mario.alvarez@itesm.mx
Fax: +52 8183284136
Tel: +52 8183582000

b Tecnológico de Monterrey at Monterrey, Departamento de Ingeniería Eléctrica y Computacional, Monterrey, N.L., México

c Tecnológico de Monterrey at Monterrey, Centro de Innovación en Diseño y Tecnología, Monterrey, N.L., México

Abstract

We report a proof-of-principle for the use of micro-devices as continuous bioreactors for the production of monoclonal antibodies. We culture CHO cells on the surface of PMMA “zigzag” channels textured with semi-spherical cavities coated with fibronectin, observing steady-state productivities 100 times higher than those observed in full scale systems.

Graphical abstract: A biopharmaceutical plant on a chip: continuous micro-devices for the production of monoclonal antibodies

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Article information

DOI
https://doi.org/10.1039/C3LC50104C
Article type
Communication
Submitted
02 Dec 2012
Accepted
23 Jan 2013
First published
11 Feb 2013

Lab Chip, 2013,13, 1243-1246

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A biopharmaceutical plant on a chip: continuous micro-devices for the production of monoclonal antibodies

L. D. Garza-García, L. M. Carrillo-Cocom, D. Araiz-Hernández, P. Soto-Vázquez, J. López-Meza, E. J. Tapia-Mejía, S. Camacho-León, E. García-López, C. A. Rodríguez-González and M. M. Alvarez, Lab Chip, 2013, 13, 1243 DOI: 10.1039/C3LC50104C

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