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Issue 12, 2013
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Probing subcellular organic hydroperoxide formation via a genetically encoded ratiometric and reversible fluorescent indicator

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Abstract

A ratiometric and reversible organic hydroperoxide (OHP) sensor, rOHSer, was developed with high sensitivity and selectivity for subcellular OHP visualization. Through targeting rOHSer to the nucleus, we demonstrated that high levels of D-glucose cause elevated OHP production in this compartment. Further utilization of rOHSer probe may allow more elucidation of unique roles of OHPs in diverse biological processes.

Graphical abstract: Probing subcellular organic hydroperoxide formation via a genetically encoded ratiometric and reversible fluorescent indicator

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Article information


Submitted
08 Oct 2013
Accepted
19 Oct 2013
First published
22 Oct 2013

Integr. Biol., 2013,5, 1485-1489
Article type
Paper

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