Multiscale modelling approach combining a kinetic model of glutathione metabolism with PBPK models of paracetamol and the potential glutathione-depletion biomarkers ophthalmic acid and 5-oxoproline in humans and rats†
Abstract
A key role of the
* Corresponding authors
a Manchester Centre for Integrative Systems Biology and Doctoral Training Centre ISBML, Manchester Interdisciplinary Biocentre, University of Manchester, 131 Princess Street, Manchester, UK
b Drug Metabolism and Pharmacokinetics IM, AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire, UK
c
Oncology iMED DMPK, AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire, UK
E-mail:
james.yates@astrazeneca.com
d Global Safety Assessment, Innovative Medicines, AstraZeneca R&D, Alderley Park, Macclesfield, UK
e Chair of Mathematical Modeling for Systems Toxicology, Université de Technologie de Compiègne, Royallieu Research Center, 60200 Compiegne, France
f INERIS, 60550 Verneuil-en-Halatte, France
g Dept of Surgery and Cancer, Sir Alexander Fleming Building, Imperial College, Exhibition Rd, South Kensington, London, UK
h Molecular Cell Physiology, VU University, Amsterdam, The Netherlands
i Systems and Synthetic Biology, FNWI, Universiteit van Amsterdam, The Netherlands
A key role of the
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