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Issue 5, 2013
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Development of a solvent selection guide for aldehyde-based direct reductive amination processes

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Abstract

A range of alternative, more environmentally conservative solvents have been evaluated for use within the direct reductive amination reactions of aldehydes using borane-based reductants. The data generated has been used to develop a guide to facilitate replacement of less desirable chlorinated solvents, such as DCE, from these widely used synthetic processes.

Graphical abstract: Development of a solvent selection guide for aldehyde-based direct reductive amination processes

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Article information


Submitted
19 Feb 2013
Accepted
09 Apr 2013
First published
09 Apr 2013

Green Chem., 2013,15, 1159-1165
Article type
Communication

Development of a solvent selection guide for aldehyde-based direct reductive amination processes

F. I. McGonagle, D. S. MacMillan, J. Murray, H. F. Sneddon, C. Jamieson and A. J. B. Watson, Green Chem., 2013, 15, 1159
DOI: 10.1039/C3GC40359A

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