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Issue 11, 2013
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Development of a robust reagent for the two-carbon homologation of aldehydes to (E)-α,β-unsaturated aldehydes in water

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Abstract

Synthesis of a new pinacolacetal-phosphonium salt and its reaction with aldehydes to give homologated acetals and two-carbon homologated unsaturated aldehydes is presented. The chemistry takes place in water under mild conditions and the sequence can be performed in one-flask operation.

Graphical abstract: Development of a robust reagent for the two-carbon homologation of aldehydes to (E)-α,β-unsaturated aldehydes in water

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Article information


Submitted
11 Jul 2013
Accepted
09 Sep 2013
First published
09 Sep 2013

Green Chem., 2013,15, 3146-3149
Article type
Communication

Development of a robust reagent for the two-carbon homologation of aldehydes to (E)-α,β-unsaturated aldehydes in water

J. McNulty, C. Zepeda-Velázquez and D. McLeod, Green Chem., 2013, 15, 3146
DOI: 10.1039/C3GC41383G

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