Issue 4, 2013
From the journal:

Green Chemistry

An eco-benign and highly efficient access to 3-heterocyclic-substituted isoindolinones in ammonia water†

Shao-Chun Shen,a   Xing-Wen Sun*a  and  Guo-Qiang Lin*a  

* Corresponding authors

a Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, P. R. China
E-mail: sunxingwen@fudan.edu.cn, lingq@mail.sioc.ac.cn
Fax: +86 (21) 65642406
Tel: +86 (21) 65642406

Abstract

A highly efficient three-component reaction of 2-formyl benzoic acid, ammonia and 4-hydroxycoumarin or indole in water was developed. With this highly environmentally benign protocol, a series of isoindolinone derivatives were efficiently produced in good to excellent yields.

Graphical abstract: An eco-benign and highly efficient access to 3-heterocyclic-substituted isoindolinones in ammonia water

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Article information

DOI
https://doi.org/10.1039/C3GC40162F
Article type
Communication
Submitted
21 Jan 2013
Accepted
22 Feb 2013
First published
25 Feb 2013

Green Chem., 2013,15, 896-900

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An eco-benign and highly efficient access to 3-heterocyclic-substituted isoindolinones in ammonia water

S. Shen, X. Sun and G. Lin, Green Chem., 2013, 15, 896 DOI: 10.1039/C3GC40162F

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